Two weeks of voluntary wheel running induces higher expression of irisin — a fat-burning hormone that is released during exercise — in bone tissue in mice. In addition, systemic administration of irisin increased bone formation and thickness, mimicking the effects of exercise on the mouse skeletal system. The findings demonstrate a potential new mechanism for the regulation of bone metabolism.
The study was led by scientists from Tufts University School of Dental Medicine (TUSDM) and published in Bone Research.
“Exercise-induced irisin may not only act as an endocrine factor capable of promoting the browning of white adipose tissue, but could also regulate bone metabolism by autocrine mechanisms,” said senior study author Jake Chen, D.M.D., M.D.S., Ph.D., professor and biological sciences researcher at TUSDM. “Our results suggest that irisin may have a therapeutic potential in strengthening bone in bone-loss-associated diseases, and additional studies are needed to evaluate the underlying mechanisms by which irisin functions.”
Exercise-based interventions work to increase bone density and reverse bone loss associated with aging. As the founder of Fitness for Health, a therapeutic, exercise facility working with children through senior citizens in the Washington, DC, area, I have seen firsthand the power of weight-bearing exercise to improve bone and joint health – especially in the middle age population and the importance of fitness for seniors. In fact, we are proud to have created a bone and joint health program for men and women as they age.
Fitness for Health provides a revolutionary, 12-week Bone and Joint Health Program for adults and seniors that capitalizes on weight-bearing, fitness activities. This groundbreaking program helps to improve posture and increase bone density, strength and balance while counteracting the effects of osteoporosis, osteopenia and aging.
The Bone and Joint Health Program elicits results faster and more effectively than traditional exercise (fitness for seniors) or pharmaceuticals through two state-of-the-art fitness technologies:
- bioDensity™ – Weight-bearing exercises are the key to stimulating bone growth, and the greater the weight applied, the better the results. The osteogenic loading that patients receive is multiples of bodyweight, and beyond what is typically seen in exercise. Research has shown, bone density gains that averaged 7% in the hip and 7.7% in the spine over one year using bioDensity (Jaquish, 2013). These results are multiples of what the current interventions can do for bone density.
- Power Plate™ – Power Plate is a whole body vibration platform that allows for reflexive engagement of the neuromuscular system at rapid and repeatable oscillation. This intervention has been clinically shown to increase balance and stability in both healthy and aging-frail populations.
When used once a week, research has shown the bioDensity system alone has significantly increased bone mass density, stability and functional movement with multiple ages, health conditions and for both genders.